Palladium‐Catalyzed CH Activation and Intermolecular Annulation with Allenes |
| |
| Authors: | Dr. Xiao‐Feng Xia Yu‐Qi Wang Dr. Lu‐Lu Zhang Dr. Xian‐Rong Song Dr. Xue‐Yuan Liu Prof. Dr. Yong‐Min Liang |
| |
| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (P.R. China), Fax: (+86)?931‐8912582;2. School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122 (P.R. China) |
| |
| Abstract: | A new and efficient PdII‐catalyzed intermolecular annulation of N‐benzoylsulfonamide with allenes for the synthesis of 3,4‐dihydroisoquinolin‐1(2H)‐ones is reported. This C?H functionalization is compatible with ambient air and moisture, and it can be applied to terminal or internal allenes with di?erent synthetically attractive functional groups. Control experiments and a kinetic isotope effect study are conducted and a plausible mechanism is proposed. |
| |
| Keywords: | allenes annulation C H activation palladium synthetic methods |
|
|
