One‐Pot Synthesis of Fused Pyrroles through a Key Gold‐Catalysis‐Triggered Cascade |
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Authors: | Zhitong Zheng Huangfei Tu Prof Dr Liming Zhang |
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Institution: | Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93117 (USA) |
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Abstract: | A two‐step, one‐pot synthesis of fused pyrroles is realized by firstly condensing an N‐alkynylhydroxammonium salt with a readily enolizable ketone under mild basic conditions and then subjecting the reaction mixture to a gold catalyst, which triggers a cascade reaction involving a facile initial 3.3]‐sigmatropic rearrangement of the gold‐catalysis product, that is, an N,O‐dialkenylhydroxamine. The reaction provides a facile access to polycyclic pyrroles in moderate to good yields. |
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Keywords: | catalysis gold hydroxamines pyrroles rearrangement |
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