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Pd–Carbene Migratory Insertion: Application to the Synthesis of Trifluoromethylated Alkenes and Dienes |
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| Authors: | Xi Wang Yan Xu Yifan Deng Yujing Zhou Jiajie Feng Guojing Ji Prof?Dr Yan Zhang Prof?Dr Jianbo Wang |
| Institution: | 1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China), Fax: (+8610)?6275‐1708;2. The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (China) |
| Abstract: | Pd‐catalyzed cross‐coupling of halides with CF3‐substituted diazo compounds or N‐tosylhydrazones has been explored for the synthesis of CF3‐substituted alkenes and 1,3‐butadienes. Pd–carbene migratory insertion plays the key role in these transformations. |
| Keywords: | alkene synthesis cross‐coupling reactions diazo compounds palladium trifluoromethylation |