Programmed Self‐Assembly of a Quadruplex DNA Nanowire |
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Authors: | Dr Nason Ma'ani?Hessari Dr Lea Spindler Tinkara Troha Dr Wan‐Chi Lam Prof Irena Dreven?ek‐Olenik Dr Mateus Webba?da?Silva |
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Institution: | 1. Biomedical Sciences Research Institute, University of Ulster, Cromore Road, Coleraine, BT51 1SA (UK);2. Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000 Maribor (Slovenia);3. Josef Sefan Institute, Jamova 39, 1000 Ljubljana (Slovenia) |
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Abstract: | The ability to produce, reproducibly and systematically, well‐defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self‐assembly of a long four‐stranded DNA nanowire through cohesive self‐assembly of GpC and CpG “sticky” ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted π‐stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double‐stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well‐defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications. |
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Keywords: | DNA G‐quadruplexes G‐wire nanowires self‐assembly |
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