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Hydrogen‐Bonding in Aminocatalysis: From Proline and Beyond |
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| Authors: | Dr ?ukasz Albrecht Dr Hao Jiang Prof?Dr Karl Anker Jørgensen |
| Institution: | 1. Department of Chemistry, Institute of Organic Chemistry, Lodz University of Technology, ?eromskiego 116, 90‐924 Lodz (Poland);2. Department of Chemistry, Center for Catalysis, Aarhus University 8000 Aarhus C (Denmark), Fax: (+45)?89196199 |
| Abstract: | This Concept article summarizes recent progress in the field of hydrogen‐bonding aminocatalysis using proline‐derived systems. The aminocatalysts available in the literature are categorized by the incorporated hydrogen‐bonding scaffold and its mode of recognition. Both mono‐ and double‐hydrogen‐bonding motifs are discussed and examples of their application in asymmetric synthesis are given. |
| Keywords: | aminocatalysis asymmetric catalysis bifunctional catalysis hydrogen bonds proline stereoselective synthesis |