Cyclic Peptides as Inhibitors of Amyloid Fibrillation |
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Authors: | Jinghui Luo Prof Jan Pieter Abrahams |
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Institution: | Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratoriesm, Einsteinweg 55 (The Netherlands) |
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Abstract: | Many neurodegenerative diseases, like Parkinson’s, Alzheimer’s, or Huntington’s disease, occur as a result of amyloid protein fibril formation and cell death induced by this process. Cyclic peptides (CPs) and their derivatives form a new class of powerful inhibitors that prevent amyloid fibrillation and decrease the cytotoxicity of aggregates. The strategies for designing CPs are described, with respect to their amino acid sequence and/or conformational similarity to amyloid fibrils. The implications of CPs for the study and possible treatment of amyloid‐related diseases are discussed. |
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Keywords: | amyloid fibrillation cyclic peptides fibrils inhibitors mimics proteins |
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