| 毛细管区带电泳法测定复方磷酸可待因溶液有效成份 |
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| 引用本文： | 饶毅,王义明,罗国安.毛细管区带电泳法测定复方磷酸可待因溶液有效成份[J].分析科学学报,2001,17(3):182-185. |
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| 作者姓名： | 饶毅 王义明 罗国安 |
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| 作者单位： | 清华大学药物研究所, |
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| 基金项目： | 国家自然科学基金 (No.2 963 5 0 2 2 0 ) |
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| 摘 要： | 应用毛细管电泳法测定了复方磷酸可待因溶液中磷酸可待因、盐酸麻黄碱、扑尔敏的含量。毛细管电泳的条件为 :37cm× 5 0 μm i.d(有效长度 30 cm)未涂层石英毛细管柱 ;分离电压 :1 5 k V;缓冲溶液 1 5 0 mmol/L NH4 Ac- H3PO4 ( p H2 .0 )。研究了方法的线性范围、精密度、回收率等 ,测定了三批样品。实验证明方法简便、快速、准确
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| 关 键 词： | 毛细管电泳法 复方磷酸可待因溶液 镇咳药 药物分析 磷酸可待因 盐酸麻黄碱 扑尔敏 |
| 文章编号： | 1006-6144(2001)02-0182-04 |
| 修稿时间： | 2000年6月16日 |
Simultaneous Determination of Active Ingredients in Compound Codeine Phosphate Solution by Capillary Electrophoresis |
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| RAO Yi,WANG Yi-ming,LUO guo-an.Simultaneous Determination of Active Ingredients in Compound Codeine Phosphate Solution by Capillary Electrophoresis[J].Journal of Analytical Science,2001,17(3):182-185. |
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| Authors: | RAO Yi WANG Yi-ming LUO guo-an |
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| Abstract: | A new capillary electrophoresis method has been developed for the determination of codeine phosphate, ephedrine hydrochloride and chlorpheniramine maleate in compound codeine phosphate solution. The method employed a 150 mmol/L ammonium acetate-phosphoric acid (pH 2.0) buffer solution, UV detection at 214 nm, electrophoresis voltage 15 kV and a capillary of 50 μm(i. d.)×37 cm. The established procedure has been applied to the determination of three batch samples. The result indicated that the proposed method was simple, rapid and reliable. |
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| Keywords: | Capillary electrophoresis Compound codeine phosphate solution Codeine phosphate Ephedrine hydrochloride Chlorpheniramine maleate |
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