Reductive methylation of primary and secondary amines and amino acids by aqueous formaldehyde and zinc |
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| Authors: | Renato A. da Silva Lothar W. Bieber |
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| Affiliation: | a Departamento de Química Fundamental, Universidade Federal de Pernambuco, Cidade Universitária, 50670-901 Recife, PE, Brazil
b Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Cabula, 41195-001 Salvador, BA, Brazil |
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| Abstract: | Amines can be methylated when treated with formaldehyde and zinc in aqueous medium. Selective mono- or dimethylation can be achieved by proper choice of pH, stoichiometry and reaction time. This method can also be applied for amino acids. |
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