The first expedient entry to the human melanogen 2-S-cysteinyldopa exploiting the anomalous regioselectivity of 3,4-dihydroxycinnamic acid-thiol conjugation |
| |
| Authors: | Lucia Panzella,Marco d&rsquo Ischia |
| |
| Affiliation: | Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Complesso Universitario Monte S. Angelo, I-80126 Naples, Italy |
| |
| Abstract: | The first convenient synthesis of 2-S-cysteinyl-3,4-dihydroxyphenylalanine (2-S-cysteinyldopa) in 30% overall yield is reported, which capitalizes on the anomalous regiochemistry of the oxidative coupling of 3,4-dihydroxycinnamic acid derivatives with thiol compounds, leading to 2-S rather than the usual 5-S conjugates. |
| |
| Keywords: | Cysteinyldopas Thiol conjugation Pheomelanin 3,4-Dihydroxycinnamic acid derivatives |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
