Preparation of 3,3-disubstituted oxindoles by addition of malonates to 3-halo-3-oxindoles |
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| Authors: | Shyam Krishnan |
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| Affiliation: | The Arnold and Mabel Beckman Laboratory for Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA |
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| Abstract: | A method for the synthesis of 3,3-disubstituted oxindole derivatives is described. This involves the base-mediated addition of malonate esters to 3-halo-3-alkyloxindoles. The addition is tolerant of a range of alkyl substituents at position 3 of the oxindole. Addition to an aryl chloro-oxindole is also described. |
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