Preparation of 3,3-disubstituted oxindoles by addition of malonates to 3-halo-3-oxindoles |
| |
| Authors: | Shyam Krishnan |
| |
| Institution: | The Arnold and Mabel Beckman Laboratory for Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA |
| |
| Abstract: | A method for the synthesis of 3,3-disubstituted oxindole derivatives is described. This involves the base-mediated addition of malonate esters to 3-halo-3-alkyloxindoles. The addition is tolerant of a range of alkyl substituents at position 3 of the oxindole. Addition to an aryl chloro-oxindole is also described. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
