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Synthesis and anti-tumor activity of all-trans retinoic acid derivatives |
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| Authors: | Juan Shena Jing Bo Shia Fei Hu Chen Yuan Wangb Jing Jing Ruana Yan Huanga a School of Pharmacy Anhui Medical University Hefei China b Key Laboratory of Gene Resource Utilization for Severe Disease Antiinflammatory Immunopharmacology Ministry of Education Anhui Province China |
| Institution: | a School of Pharmacy, Anhui Medical University, Hefei 230032, China;b Key Laboratory of Gene Resource Utilization for Severe Disease, Antiinflammatory and Immunopharmacology, Ministry of Education and Anhui Province, Anhui Medical University, Hefei 230032, China |
| Abstract: | A series of retinoate and retinamide derivatives were designed,synthesized,and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays(FCM).All compounds showed cytotoxicity,especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid(ATRA).Furthermore,compound 1d could induce NB4 cell lines differentiation efficiently. |
| Keywords: | All-trans retinoic acid Synthesis Cell differentiation NB4 cell lines |
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