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An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes |
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| Authors: | Shirong Zhu Shuhao ShiSamuel W. Gerritz |
| Affiliation: | Early Discovery Chemistry, Bristol-Myers Squibb Co., Wallingford, CT 06492, United States |
| Abstract: | An efficient protocol for the one-pot preparation of alkyl 3-aryl-5-methylisoxazole-4-carboxylates from aryl aldehydes is described. This method is readily amenable to the large scale preparation of isoxazoles as well as the parallel synthesis of isoxazole libraries. |
| Keywords: | One-pot synthesis Isoxazoles Parallel synthesis Library synthesis 1,3-Dipolar cycloaddition |
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