Extractive-spectrophotometric determination of amine-type stimulants and antidepressants with anionic indicator dyes |
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Authors: | Erol Erçağ Gülseren Sarioğlu Ayşem Üzer Taner Bora Reşat Apak |
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Affiliation: | 19912. Faculty of Engineering, Department of Chemistry, Istanbul University, Avcilar, Istanbul, 34320, Turkey 29912. Police Criminology Laboratory, Muratpasa, Antalya, Turkey
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Abstract: | Amphetamines having a stimulant effect on the central nervous system, certain antidepressants, and slimming agents containing sibutramine bear the cationic amine constituents that can form colored ion-association complexes with anionic basic dyes (i.e. bromocresol purple (BCP), methyl orange (MeO), and eriochrome black-T (EBT)), and be extracted into organic solvents for spectrophotometric determination. The limit of detection (LOD, mg/L) of the tested amines varied within the following intervals: MDMA: 0.09–0.33; MDA: 0.14–1.43; fluoxetine: 0.09–0.24; sibutramine: 0.07–0.28, depending on the dye. The proposed rapid and cost-effective extractive-photometric method for MDMA, fluoxetine, and sibutramine was statistically validated against HPLC using ecstasy, prozac, and lida pharmaceutical tablets. |
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