| 金属离子存在下5-氟尿嘧啶与脱氧核糖核酸、血清白蛋白的相互作用 |
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| 引用本文： | 卢继新,张贵珠,王月梅.金属离子存在下5-氟尿嘧啶与脱氧核糖核酸、血清白蛋白的相互作用[J].分析化学,2001,29(2):192-194. |
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| 作者姓名： | 卢继新 张贵珠 王月梅 |
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| 作者单位： | 1. 天津医科大学药学院,
2. 南开大学化学系, |
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| 基金项目： | 国家自然科学基金!（No．29575200），天津医科大学自然科学基金资助课题。 |
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| 摘 要： | 用紫外光谱、荧光光谱、圆二色谱法等方法研究了抗癌药物5－氟尿嘧啶（5－fluorouracil,5-FU）DNA、血清蛋白的相互作用及某些二阶金属离子对其作用的影响。求得5－FU与HSA、BSA的结合常数。
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| 关 键 词： | 5－氟尿嘧啶 脱氧核糖核酸 血清白蛋白 金属离子 抗肿瘤药物 药理作用 药物代谢 |
The Interaction of 5-Fluorouracil with Deoxyribonucleic Acid and Serum Albumin |
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| Lu Jixin,Zhang Guizhu,Wang Yuemei.The Interaction of 5-Fluorouracil with Deoxyribonucleic Acid and Serum Albumin[J].Chinese Journal of Analytical Chemistry,2001,29(2):192-194. |
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| Authors: | Lu Jixin Zhang Guizhu Wang Yuemei |
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| Abstract: | The interaction of 5-fluorouracil (5-FU) with deoxyribonucleic acid (DNA) and serum albumin and the influence of some metal ions on the interaction have been studied by using spectral methods of UV-absorption,fluorescence and circular dichroism. It was shown that the interaction of 5-FU with DNA and serum albumin was effected by some metal ions. The binding costant of 5-FU with serum albumin was found to be KHSA = 4.38 × 103(mol/L)-1 and KBSA =4.95 × 103(mol/L)-1 and the distance between the bound 5-FU and the tryptophan residue was also determined to be rHSA = 3.53 nm, rBSA = 3.51 nm. |
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| Keywords: | Fluorourail deoxyribonucleic acid serum albumin |
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