Expedient synthesis and structure-activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids |
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Authors: | Chuang Ta-Hsien Lee Shiow-Ju Yang Cheng-Wei Wu Pei-Lin |
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Institution: | Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan, ROC. |
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Abstract: | The total synthesis of alkaloids phenanthroindolizidine 1a, tylophorine 1b, and phenanthroquinolizidine 1c, has been achieved in 46%, 49%, and 42% overall yield, respectively, starting from the corresponding phenanthrene-9-carboxaldehyde. Compound exhibited potent inhibition activity in three human cancer cell lines, with IC(50) values ranging from 104 to 130 nM. The structure-activity relations of these alkaloids and some of their synthetic intermediates against the three cell lines were also described. |
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