Allylic C(sp3)–H alkylation via synergistic organo- and photoredox catalyzed radical addition to imines |
| |
| Authors: | Jiaqi Jia Rajesh Kancherla Magnus Rueping Long Huang |
| |
| Institution: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen Germany.; KAUST Catalysis Center, KCC, King Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900 Saudi Arabia |
| |
| Abstract: | A new catalytic method for the direct alkylation of allylic C(sp3)–H bonds from unactivated alkenes via synergistic organo- and photoredox catalysis is described. The transformation achieves an efficient, redox-neutral synthesis of homoallylamines with broad functional group tolerance, under very mild reaction conditions. Mechanistic investigations indicate that the reaction proceeds through the N-centered radical intermediate which is generated by the allylic radical addition to the imine.A new catalytic method for the direct alkylation of allylic C(sp3)–H bonds from unactivated alkenes via synergistic organo- and photoredox catalysis is described. |
| |
| Keywords: | |
|
|
