| Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS) |
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| 引用本文： | 陈晓明,张健,田庚元. Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS)[J]. 中国化学, 2002, 20(11): 1406-1410. DOI: 10.1002/cjoc.20020201142 |
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| 作者姓名： | 陈晓明 张健 田庚元 |
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| 作者单位： | CHEN，Xiao-Ming ZHANG，Jian TIAN，Geng-Yuan State Key Laboratory of Bioorganic & Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | theMinistryofScienceandTechnology ,China (No .970 2 110 0 6 4 4 ) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＩｔｉｓｗｅｌｌｋｎｏｗｎｔｈａｔｔｈｅｌｉｐｏｐｏｌｙｓａｃｃｈａｒｉｄｅｓａｒｅｃａ ｐａｂｌｅｏｆｒｅｖｅａｌｉｎｇａｖａｒｉｅｔｙｏｆｂｉｏｌｏｇｉｃａｌａｃｔｉｖｉｔｉｅｓｉｎｃｌｕｄ ｉｎｇｔｕｍｏｒ ｇｒｏｗｔｈｉｎｈｉｂｉｔｏｒｙａｃｔｉｖｉｔｙ .1Ｐｈｏｓｐｈｏｒｙｌａｔｉｏｎｏｆｐｏｌｙｓａｃｃｈａｒｉｄｅｓｈａｓａｔｔｒａｃｔｅｄｗｉｄｅｓｐｒｅａｄａｔｔｅｎｔｉｏｎｂｅｃａｕｓｅｉｔｗａｓｒｅｐｏｒｔｅｄｔｈａｔｔｈｅｙｓｈｏｗａｎｔｉｔｕｍｏｒａｃｔ…
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Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS) |
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| CHEN,Xiao-Ming ZHANG,Jian TIAN,Geng-Yuan State Key Laboratory of Bioorganic , Natural Products Chemistry. Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS)[J]. Chinese Journal of Chemistry, 2002, 20(11): 1406-1410. DOI: 10.1002/cjoc.20020201142 |
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| Authors: | CHEN Xiao-Ming ZHANG Jian TIAN Geng-Yuan State Key Laboratory of Bioorganic & Natural Products Chemistry |
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| Affiliation: | CHEN,Xiao-Ming ZHANG,Jian TIAN,Geng-Yuan State Key Laboratory of Bioorganic & Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | The synthesis of phosphorylated Achyranthes bidentata polysaccharide (P-AbPS) was reported based on different strategies. The P-AbPS with high degree of substitution (D.S.>0.5) was obtained when phosphorus oxychloride (POCl 3) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide was used as solvent. The influences of different solvents and reaction conditions were discussed. The pharmacology assay shows that P-AbPS possesses antitumor activity against sarcoma 180 and Lewis lung cancer in mice. |
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| Keywords: | phosphorylation polysaccharide Achyranthes bidentata antitumor |
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