Synthesis,structural characterization,and immunological properties of carbon nanotubes functionalized with peptides |
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Authors: | Pantarotto Davide Partidos Charalambos D Graff Roland Hoebeke Johan Briand Jean-Paul Prato Maurizio Bianco Alberto |
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Affiliation: | Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France. |
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Abstract: | Carbon nanotubes (NTs) are becoming highly attractive molecules for applications in medicinal chemistry. The main problem of insolubility in aqueous media has been solved by developing a synthetic protocol that allows highly water-soluble carbon NTs to be obtained. As a result, biologically active peptides can be easily linked through a stable covalent bond to carbon NTs. We have demonstrated that a bound peptide from the foot-and-mouth disease virus, corresponding to the 141-159 region of the viral envelope protein VP1, retained the structural integrity and was recognized by monoclonal and polyclonal antibodies. In addition, this peptide-NT conjugate is immunogenic, eliciting antibody responses of the right specificity. Such a system could be greatly advantageous for diagnostic purposes and could find future applications in vaccine delivery. |
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