Hemoglobin dendrimers: functional protein clusters |
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| Authors: | Kluger Ronald Zhang Jie |
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| Affiliation: | Davenport Chemical Research Building, Department of Chemistry, University of Toronto, Ontario, Canada M5S 3H6. rkluger@chem.utoronto.ca |
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| Abstract: | A cluster of cross-linked hemoglobin tetramers was prepared by conjugating active esters to amino groups of a starburst dendrimer. Comparison of oxygen-binding properties of the protein cluster to those of nonclustered species reveals an increase in affinity and a decrease in cooperativity in the cluster. The altered oxygen-binding properties are assigned to protein-protein interactions. |
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