Synthesis,Physicochemical and Pharmacological Properties of N,N',N', N'-Substituted Amides of 1,1,3,3-Propanetetracarboxylic Acid |
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Authors: | Bezuglyi P A Georgiyants V A Perekhoda L A Garnaya N V Sych I A |
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Institution: | (1) Ukrainian Pharmaceutical Academy, Kharkov, Pushkinskaya ul., 53, Ukraine, 61002 |
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Abstract: | By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N',N'-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity. |
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