| 层状复合氢氧化物对乙酰苯甲酸的负载与体外释放 |
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| 引用本文： | 苟国敬,许红平,刘建平. 层状复合氢氧化物对乙酰苯甲酸的负载与体外释放[J]. 化学学报, 2009, 67(1): 65-82 |
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| 作者姓名： | 苟国敬 许红平 刘建平 |
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| 作者单位： | 宁夏医科大学基础学院,银川,750004 |
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| 基金项目： | 教育部科学技术研究重点项目，宁夏自然科学基金，宁夏高等学校科学技术研究基金，宁夏医学院特殊人才科研启动基金 |
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| 摘 要： | 共沉淀-微波晶化法合成层状复合氢氧化物(LDH)后, 用不同方式将乙酰苯甲酸(ASP)组装到LDH层间制成载药体LDH-ASP, 通过对合成及药物释放前后的液相分析与固相表征数据研究了LDH对ASP的负载及载药体LDH-ASP在磷酸盐介质的溶释现象. 结果表明: LDH层间通道是负载、贮存及控制药物释放的微观基础; 载体选择、药物配比、反应能量供给方式及搅拌强度是决定并影响LDH-ASP载药效率的基本因素, LDH-ASP结构参数可以反映药物负载情况、并与其释放性能明确相关; LDH对ASP的负载与释放均致晶胞参数改变、结晶度下降; 载药体与前体的晶态属性、热力学行为及表面特性相似, 而释放药物后固相的晶态性征减弱、无定形性增强、通道吸附活性降低, 有利于使命后载体在体内降解消除.
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| 关 键 词： | LDH 载药体系 结晶度 负载效率 药物释放 |
| 收稿时间： | 2007-10-12 |
| 修稿时间： | 2007-12-16 |
Loading and in vitro Release of Acetylsalicylic Acid via Layered Double Hydroxides |
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| Gou, Guojing,Xu, Hongping,Liu, Jianping. Loading and in vitro Release of Acetylsalicylic Acid via Layered Double Hydroxides[J]. Acta Chimica Sinica, 2009, 67(1): 65-82 |
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| Authors: | Gou Guojing Xu Hongping Liu Jianping |
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| Affiliation: | School of Basic Medical Science;Ningxia Medical University;Yinchuan 750004 |
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| Abstract: | Layered double hydroxide LDH, obtained by a co-precipitation-microwave crystallization process, has been used as precursors to intercalate a model drug, antipyretic agent acetylsalicylic acid (ASP) to prepare a modified release formulation via different reaction patterns. The loading capacity and drug release process in phosphates have been investigated via analyzing both liquid phase and solid phase samples taken early or late respectively from intercalation and release reaction systems. The result showed ... |
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| Keywords: | LDH |
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