Rhodium-catalyzed asymmetric synthesis of indanones: development of a new "axially chiral" bisphosphine ligand |
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| Authors: | Shintani Ryo Yashio Keiji Nakamura Tomoaki Okamoto Kazuhiro Shimada Toyoshi Hayashi Tamio |
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| Affiliation: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. |
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| Abstract: | A rhodium-catalyzed asymmetric isomerization of racemic alpha-arylpropargyl alcohols to beta-chiral indanones has been developed. High enantioselectivity has been realized by the use of a newly developed axially chiral bisphosphine ligand. This ligand is unique in the sense that its axial chirality is fixed to a single configuration upon complexation to a transition metal due to other chiral axes existing within the same molecule. |
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