| 负载生物活性功能基聚醚氨酯的表面自由能与表面血液相容性研究 |
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| 引用本文： | 陈宝林,计剑,季任天,邱永兴,封麟先. 负载生物活性功能基聚醚氨酯的表面自由能与表面血液相容性研究[J]. 应用化学, 2001, 18(5): 384-0 |
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| 作者姓名： | 陈宝林 计剑 季任天 邱永兴 封麟先 |
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| 作者单位： | 内蒙古呼伦贝尔学院，浙江大学 |
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| 基金项目： | 国家自然科学基金资助项目(29804009) |
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| 摘 要： | 水相接触角;负载生物活性功能基聚醚氨酯的表面自由能与表面血液相容性研究
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| 关 键 词： | 水相接触角 负载生物活性功能基聚醚氨酯的表面自由能与表面血液相容性研究 |
| 文章编号： | 1000-0518(2001)05-0384-05 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2001-01-08 |
Surface Property and BloodCompatibility of Biomolecular Modified Polyurethane |
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| CHEN Bao-Lin a,b,JI Jian b,JI Ren-Tian b,FENG Lin-Xian b. Surface Property and BloodCompatibility of Biomolecular Modified Polyurethane[J]. Chinese Journal of Applied Chemistry, 2001, 18(5): 384-0 |
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| Authors: | CHEN Bao-Lin a b JI Jian b JI Ren-Tian b FENG Lin-Xian b |
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| Affiliation: | CHEN Bao-Lin a,b,JI Jian b,JI Ren-Tian b,FENG Lin-Xian *b |
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| Abstract: | A series of biomolecular modified polyurethane were prepared. PEU-g-PEO-SO3Na, PEU-g-PEO-C18, PEU-g-PEO-SO2Lys, PEU-g-PEO-SO2Tyr, their surface properties were investigated bycontact angle measurement. The polymer-water interface free energy γ＇sw, the contribution of itspolarity γpsv and its non-polarity γdsvwere obtained by using captive bubble method. The results indicatethat in the sulfonate modified PEU surface, the value of γsw increased with the content of PEO. WhenLys or Tyr was grafted on the end of sulfonate PEU side chain, γsw decreased. The bloodcompatibility of the biomolecular modified polyurethanes was determined by measurements of plateletadhesion, plasma recalcification time(RTT) and prothrombin time(PTT). All biomolecular modifiedpolyurethanes show good blood compatibility and potential in coating materials in blood contactdevice. |
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| Keywords: | bioactive moiety functionalized polyurethane contact angle blood compatibity |
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