Triflic acid-catalyzed highly stereoselective friedel-crafts aminoalkylation of indoles and pyrroles |
| |
Authors: | Abid Mohammed Teixeira Liliana Török Béla |
| |
Institution: | Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, Massachusetts 02125-3393, USA. |
| |
Abstract: | A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched alpha-trifluoromethyl-alpha-(heteroaryl)-glycine derivatives via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3-trifluoro-pyruvate-alpha-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group provided the products in high yields and excellent enantioselectivities. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|