Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis |
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| Authors: | Subramanian Thangaiah Wang Zhongwen Troutman Jerry M Andres Douglas A Spielmann H Peter |
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| Affiliation: | Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536-0084, USA. |
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| Abstract: | [reaction: see text]. A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)4N)3HP2O7. |
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