A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes |
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| Authors: | Sivakumar Krishnamoorthy Xie Fang Cash Brandon M Long Su Barnhill Hannah N Wang Qian |
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| Affiliation: | Department of Chemistry & Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA. |
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| Abstract: | Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications. [reaction: see text] |
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