Formation of lysozyme fibrils on a solid support

The formation of lysozyme fibrils on a solid support was studied with a FemtoScan? atomic force microscope. It is found that, at room temperature and pH 3, when aggregation in solution is absent, the fibrils can be formed on the surface. It is shown that the proximity of lysozyme molecules to the surface favors their aggregation. The physical sorption of lysozyme on the gold surface does not result in aggregation, and the chemical grafting of lysozyme to the gold surface is favorable for the fibril formation. The force of interaction of lysozyme molecules immobilized on the gold surface of a cantilever was measured on an Atomic Balance?.