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Ferrocene derivatives supported on poly(N-vinylpyrrolidin-2-one) (PVP): Synthesis of new water-soluble electrochemically active probes for biomolecules |
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| Authors: | Clara Baldoli Claudio Oldani Prasanna Ramani Paolo Ferruti Patrizia Mussini |
| Institution: | a CNR-Institute of Molecular Science and Technologies, Via C. Golgi 19, I-20133 Milano, Italy b Department of Organic and Industrial Chemistry, University of Milan, Via G. Venezian 21, I-20133 Milano, Italy c Department of Physical Chemistry and Electrochemistry; University of Milan, Via C. Golgi 19, I-20133 Milano, Italy |
| Abstract: | Carboxy-terminated polyvinylpyrrolidin-2-one (PVP) has been used as a new water-soluble and biocompatible polymeric support for a series of ferrocene labeled amino acid and peptide nucleic acid (PNA) monomer derivatives 4-7. The organometallic polymer-conjugates thus obtained are new and potentially useful as water-soluble electrochemically active probes for biomolecules. In view of such application, their electrochemical activity has been evaluated and has proved very high notwithstanding the complexity and bulkiness of the molecule, affording detection limits down to 10−8 M in the aqueous medium. |
| Keywords: | Bioorganometallic chemistry Ferrocene Functionalized PVP Electrochemically active probes Polymer conjugation |
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