Gene expression changes following extinction testing in a heroin behavioral incubation model |
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| Authors: | Kara L Kuntz-Melcavage Robert M Brucklacher Patricia S Grigson Willard M Freeman and Kent E Vrana |
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| Institution: | (1) Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA;(2) Functional Genomics Core Facility, Pennsylvania State University College of Medicine, Hershey, PA, USA;(3) Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA |
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| Abstract: | Background A number of gene expression studies have investigated changes induced by drug exposure, but few reports describe changes that
persist following relapse. In this study, genome-wide analysis of gene expression was conducted following an extinction session
(90 min) in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. As an important modulator
of goal-directed behavior, the medial prefrontal cortex (mPFC) was the target of genomic analysis. Rats were trained to self-administer
heroin during 3 h daily sessions for 14 d. Following the self-administration period, rats were reintroduced to the self-administration
chambers for a 90-minute extinction session in which they could seek heroin, but received none. Extinction sessions were conducted
on groups after either 1 d or 14 d of drug-free enforced abstinence to demonstrate behavioral incubation. |
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