Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing32P as well as for the estimation of99 Mo and199Au |
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| Authors: | S. Trebert Haeberlin F. Lux J. Karl T. Spruss H. Schönenberger |
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| Affiliation: | (1) Institut für Radiochemie der Technischen Universität München, Walther-Meißner-Straße 3, D-8046 Graching, (FRG);(2) Lehrstuhl für Pharmazeutische Chemie II, Universität Regensburg, Universitätsstraße 31, D-8400 Regensburg, (FRG) |
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| Abstract: | As part of an examination of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of platinum and biologically essential trace elements of tumour tissue and different organs were determined. The activation analysis procedure — separation of32P, isolation of199Au and99Mo — is described. In the course of a pharmakokinetical experiment with tumourbearing rats (DMBA induced hormone-dependent tumours) the desired enrichment of the administered drug in the tumour tissue was found. Changes of the trace element level of tumour tissue were found for hormone-dependent MXT-mammary tumours on mice. |
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