Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality |
| |
Authors: | Paravidino Monica Bon Robin S Scheffelaar Rachel Vugts Danielle J Znabet Anass Schmitz Rob F de Kanter Frans J J Lutz Martin Spek Anthony L Groen Marinus B Orru Romano V A |
| |
Affiliation: | Vrije Universiteit Amsterdam, Department of Chemistry, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. |
| |
Abstract: | [Structure: see text] In a search for new multicomponent strategies leading to valuable small heterocycles, a new highly diastereoselective four-component reaction (4CR) was found in which a phosphonate, nitriles, aldehydes, and isocyanoacetates combine to afford functionalized 3-isocyano-3,4-dihydro-2-pyridones. In this strategy, initially a 1-azadiene is generated, which is trapped in the same pot by an isocyanoacetate as the fourth component. Multicomponent reactions (MCRs) that lead to heterocycles containing isocyano substituents are unprecedented and offer many possibilities for further differentiation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|