Partial Synthesis of 3′-Hydroxy-2′-deoxy-2″,3″,4″,5″-tetrahydroverrucarin A. Verrucarins and roridins, 38th Communication [1]

The macrocyclic trichothecene triester 3′-hydroxy-2′-deoxy-2",3",4",5"-tetrahydroverrucarin A ( 37 ), has been synthesized starting from the sesquiterpene alcohol verrucarol ( 3 ), adipic acid and a derivative of mevalonic acid ( 14 ). The latter has been prepared from 4-(tetrahydro-2-pyranyloxy)-2-butanone ( 9 ).