Technische Verfahren zur Synthese von Carotinoiden und verwandten Verbindungen aus 6-Oxo-isophoron. II. Ein neues Konzept für die Synthese von (3RS, 3′RS)-Astaxanthin |
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Authors: | Erich Widmer Reinhard Zell Emil Albin Broger Yvo Crameri Hans Peter Wagner Josef Dinkel Markus Schlageter Todor Luk
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Institution: | Erich Widmer,Reinhard Zell,Emil Albin Broger,Yvo Crameri,Hans Peter Wagner,Josef Dinkel,Markus Schlageter,T+odor Lukáč |
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Abstract: | Technical Procedures for the Synthesis of Carotenoids and Related Compounds from 6-Oxo-isophorone. II. A Novel Concept for the Synthesis of (3RS, 3′RS)-Astaxanthin Starting from 6-oxo-isophorone ( 2 ) a new concept for a seven-step synthesis of (3RS, 3′RS)-astaxanthin ( 1 ) has been developed. As a key feature of the new approach, the oxidation state of astaxanthin ( 1 ) is adjusted already at an early stage of the synthesis. Thus, manipulation on more complex intermediates later in the synthesis is reduced to a minimum. Acetonide 10 or dimer 13 represent the key intermediates of this concept (Scheme 2). The whole sequence has been run on a kg scale with an overall yield of 52% (s. Scheme 5). |
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