Ring opening reaction of 3,6-Dihydro-2-(1H)pyrimidinones with hydroxylamine hydrochloride |
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| Authors: | Choji Kashima Akira Katoh Yuko Yokota Yoshimari Omote |
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| Abstract: | 1,4,6-Trisubstituted 3,6-dihydro-2-(1H)pyrimidinones (Ia-d) easily underwent the ring opening reaction with hydroxylamine hydrochloride to afford the oximes (IIa-d) in good yields. In the case of 3,6-dihydro-6-methyl-I-phenyl-2-(1H)pyrimidinone (Ie), 2-anilinobutyronitrile (III) was obtained in addition to the oxime (IIe). Dihydro-2-(1H)pyrimidinone (IV) and -thiones (V and VI) did not undergo the ring opening reaction. |
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