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Matrix assisted pulsed laser evaporation of poly(d,l-lactide) thin films for controlled-release drug systems |
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| Authors: | R Cristescu A Doraiswamy G Socol E Axente RJ Narayan A Moldovan IN Mihailescu DB Chrisey |
| Institution: | a National Institute for Laser, Plasma and Radiation Physics, P.O. Box MG-36, RO-77125, Bucharest, Romania b Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA c Edwards Lifesciences, Irvine, CA, USA d University of Agriculture Sciences and Veterinary Medicine, 59 Marasti, Bucharest, Romania e University of Bucharest, Faculty of Physics, P.O. Box MG-11, 3Nano-SAE Research Center, Bucharest-Magurele, Romania f Center for Nanoscale Science and Engineering, North Dakota State University, 1805 NDSU Research Park Drive, Fargo, ND, USA g Rensselaer Polytechnic Institute, Department of Material Science, 110 8th Street, Troy 12180-3590, NY, USA |
| Abstract: | We report the successful deposition of the porous polymer poly(d,l-lactide) by matrix assisted pulsed laser evaporation (MAPLE) using a KrF* excimer laser (248 nm, τ = 7 ns) operated at 2 Hz repetition rate. The chemical structure of the starting materials was preserved in the resulting thin films. Fluence played a key role in optimizing our depositions of the polymer. We demonstrated MAPLE was able to improve current approaches to grow high quality thin films of poly(d,l-lactide), including a porosity control highly required in targeted drug delivery. |
| Keywords: | Controlled drug release Porous polymers Thin films Matrix assisted pulsed laser evaporation |
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