Thiolated polyethylene oxide as a non-fouling element for nano-patterned bio-devices |
| |
Authors: | Patrícia Lisboa |
| |
Institution: | European Commission, Joint Research Centre-Institute for Health and Consumer Protection, Via E.Fermi, 1 TP203, 21020 Ispra (Varese), Italy |
| |
Abstract: | This work describes the synthesis of a thiolated polyethylene oxide that self-assembles on gold to create a non-fouling surface. Thiolated polyethylene oxide was synthesised by reacting 16-mercaptohexadecanoic acid with polyethylene glycol mono methyl ether. The coverage of the thiolated polyethylene oxide on gold was studied by cyclic voltammetry, and the modified surfaces were characterised by X-ray photoelectron spectroscopy and ellipsometry. Protein resistance was assessed using quartz crystal microbalance. Results showed a non-fouling character produced by the thiolated polyethylene oxide. The synthesised product was used as the passivation layer on nano-patterned surfaces consisting of arrayed nano-spots, fabricated by plasma based colloidal lithography. The specific adsorption of anti-bovine serum albumin in the mercaptohexadecanoic acid spots was verified by atomic force microscopy. |
| |
Keywords: | 87 68 +z 81 16 Dd 81 16 Nd |
本文献已被 ScienceDirect 等数据库收录! |
|