Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione |
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| Authors: | P. A. Poluboyarinov P. P. Leshchenko I. Ya. Moiseeva S. G. Kolesnikova N. B. Epshtein |
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| Affiliation: | 1.Penza State University of Architecture and Construction,Penza,Russia;2.Penza State University,Penza,Russia;3.National Research Nuclear University MEPhI,Obninsk,Russia |
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| Abstract: | Products of reaction between the organoselenium xenobiotic, diacetophenonyl selenide (1,5-diphenyl-3-selenapenta-1,5-dione), and reduced glutathione at different molar ratios and pH values were studied by HPLC and TLC. Reaction intermediates, S-(acetophenylselenyl)glutathione and glutathione selenodisulfide, and reaction products, acetophenone and hydroselenide anion, were detected. The reaction scheme proposed earlier was confirmed. |
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