| 柱色谱分离蔗糖酰化产物中蔗糖-6-乙酸酯的研究 |
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| 引用本文： | 邓丽杰,陈平.柱色谱分离蔗糖酰化产物中蔗糖-6-乙酸酯的研究[J].化学研究与应用,2006,18(12):1456-1459. |
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| 作者姓名： | 邓丽杰 陈平 |
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| 作者单位： | 浙江大学化学系,浙江,杭州,310028;浙江大学化学系,浙江,杭州,310028 |
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| 摘 要： | 通过蔗糖C-6位羟基的选择性乙酰化反应,合成的蔗糖-6-乙酸酯是进一步制备卤代蔗糖衍生物的重要中间体1]。三氯蔗糖是目前被广泛关注的一种新型卤代蔗糖衍生物2],它是以天然的蔗糖为原料,经半化学合成而得到的强力甜味剂,具有高甜度、低热值、无毒和抗龋齿等特点。在众多的三氯蔗糖的合成方法中3-5],必须首先要对活泼的蔗糖C-6位羟基进行保护,即蔗糖的选择性酰化反应。蔗糖的乙酰化产物中除蔗糖-6-乙酸酯外,还有未转化的原料蔗糖和部分反应副产物。因此,为了减轻后续工艺合成的难度,降低制备成本,使最终产物三氯蔗糖容易提纯,必须对酰化…
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| 关 键 词： | 蔗糖 蔗糖-6-乙酸酯 离子交换树脂 吸附分离 |
| 文章编号： | 1004-1656（2006）12-1456-04 |
| 收稿时间： | 2005-12-13 |
| 修稿时间： | 2006-03-30 |
Separation of sucrose-6-acetate from acetylation product of sucrose by the column chromatography |
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| DENG Li-jie,CHEN Ping.Separation of sucrose-6-acetate from acetylation product of sucrose by the column chromatography[J].Chemical Research and Application,2006,18(12):1456-1459. |
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| Authors: | DENG Li-jie CHEN Ping |
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| Institution: | Department of Chemistry,Zhejiang University, Hangzhou 310028,China |
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| Abstract: | The separation and purification of sucrose6-acetate from acetylation product of sucrose by PUROLITE PCR(Ca) ion exchange resin were invesigaged.It was found that the adsorption velocity of sucrose-6-acetate on ion exchange resin was corresponding to sucrose,but the dynamic permeable adsorption capacity of sucrose was larger than that of sucrose-6-caetate.The resolution of the samples on column chromatography could generally be enhanced with the increase of the ration of column height to diameter,decreased with the increase of the loading quantity and the flowing velocity.Under the typical separation operation conditions,the content of sucrose-6-acetate could reach about 94 from 80.7%,and the average separation yield was about 85.0%. |
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| Keywords: | sucrose sucrose-6-acetate ion exchange resin adsorpaion separation |
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