Structural properties of nonionic surfactant/glycerol/paraffin lyotropic liquid crystals |
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| Authors: | Makai Melinda Csányi Erzsébet Dékány Imre Németh Zsolt Erős István |
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| Affiliation: | (1) Department of Pharmaceutical Technology, University of Szeged, Eötvös utca 6., 6720 Szeged, Hungary;(2) Department of Colloid Chemistry, University of Szeged, Aradi Vértanuk tere 1., 6720 Szeged, Hungary;(3) Department of Physical Chemistry, Technical University of Budapest, 8 Budafoki út 8., 1111 Budapest, Hungary; |
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| Abstract: | Lamellar lyotropic liquid-crystalline systems are thermodynamically stable, optically isotropic and are formed spontaneously. New possibilities for the development of controlled drug delivery systems are inherent in these systems in consequence of their stability and special, skin-friendly structure. The aim was to formulate and study two-component or multicomponent compositions with a relatively low Brij 96V content, liquid paraffin, glycerol and water for therapeutic purposes. The liquid crystals were examined by polarizing light microscopy and transmission electron microscopic observation of replicas produced by the freeze–fracture technique to demonstrate the presence of lamellar liquid-crystalline domains. The existence of a regular structure was determined by X-ray diffraction. |
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