Retention and enantioselectivity properties of β-cyclodextrin polymers and derivatives on porous silica for reverse-phase liquid chromatographic separation of enantiomers |
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Authors: | B Sébille M Guillaume C Vidal-Madjar N Thuaud |
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Institution: | (1) Laboratoire de Physico-Chimie des Biopolymères, Unité Mixte CNRS, Université de Paris XII n0 27, 2 rue Henri Dunant, 94320 Thiais, France |
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Abstract: | Summary Chiral stationary phases (CSP) based on porous silica coated with β-cyclodextrin polymer and methylated or acetylated derivatives
have been prepared. Their enantiomer separation capability was tested and compared under reversed-phase mode elution conditions.
Noticeable changes in retention properties werenoted and in many cases a reverse enantioselectivity was evidenced, as a consequence
of a strong modification of the energy, geometry and number of points of contact between solutes and stationary phase sites
of molecular recognition.
Presented at the 21st ISC held in Stuttgart, Germany, 15th–20th September, 1996. |
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Keywords: | Column liquid chromatography Chiral stationary phase β -Cyclodextrin polymer and methylated and acetylated derivatives Enantioselectivity |
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