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Agelasines O-U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp. |
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| Authors: | Takaaki KubotaTakahiro Iwai Azusa Takahashi-NakaguchiJane Fromont Tohru GonoiJun'ichi Kobayashi |
| Affiliation: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan b Mycology Research Center, Chiba University, Chiba 260-0856, Japan c Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia |
| Abstract: | New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi. |
| Keywords: | Marine sponge Agelas sp. Diterpene alkaloid Bromopyrrole alkaloid Agelasines O-U Antimicrobial activity |
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