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3,4-seco-Diterpenoids from Trigonostemon flavidus |
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| Authors: | Gui-Hua Tang Hong-Ping HeYu-Cheng Gu Ying-Tong DiYue-Hu Wang Shi-Fei Li Shun-Lin LiYu Zhang Xiao-Jiang Hao |
| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China b Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China c Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK d Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China |
| Abstract: | Phytochemical investigation on the stems of Trigonostemon flavidus resulted in the isolation of five new 3,4-seco-diterpenoids, trigoflavidones A-E (1-5), structurally related to the main co-occurring known 3,4-seco-sonderianic acid (6) and 3,4-seco-sonderianol (7). Compound 4 possesses new 3,4-seco rearranged ent-pimarane skeletal type, characteristic of a vinyl group at C-8, while 5 features a unique five-membered ring (C1) fused with a cyclopropane ring (C2). The structures of the new compounds were established by a combination of spectroscopic data and computational methods. Compounds 1-7 were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. |
| Keywords: | Euphorbiaceae Trigonostemon flavidus 3,4-seco-Diterpenoids Trigoflavidones A-E |
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