FIA-spectrophotometric determination of N-substituted phenothiazine derivatives by oxidation with a solid-phase reactor of manganese dioxide incorporated in polyester resin beads |
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Authors: | Kojło A Calatayud J M |
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Institution: | Institute of Chemistry, Warsaw University Branch at Bia?ystok, 15-443 Bia?ystok, Poland. |
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Abstract: | The determination of several N-substituted phenothiazine derivatives was carried out by the reaction of the drug with managanese dioxide entrapped in a polymeric material in a packed-bed reactor; the oxidized drug was monitored at lambda(max). The calibration graph is linear over the range 5-50 mug/ml of phenothiazine derivatives with a relative standard deviation of 0.5-1% (at 10 mug/ml) and sample throughput of 40-48 h(-1). The influence of foreign compounds was studied and the method was applied to the determination of six different phenothiazine derivatives in pharmaceutical formulations. |
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