Quantitative non-destructive determination of salicylic acid acetate in aspirin tablets by Raman spectroscopy |
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| Authors: | Kontoyannis C G Orkoula M |
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| Affiliation: | Institute of Chemical Engineering and High Temperature Chemical Processes, and Department of Pharmacy, University of Patras, Patras, Greece. |
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| Abstract: | Laser Raman spectroscopy was used for the quantitative determination of aspirin in aspirin-maize starch tablets. A calibration curve was constructed from spectra obtained from tablets with known quantities of aspirin and starch. The calibration curve is given from the relationship: I(552)/I(478) = (W(aspirin)/W(starch)) x 4.21, where I(552) and I(478) are the relative Raman intensities for the 552 and 478 cm(-1) Raman shift, respectively. W(aspirin) and W(starch) represent the weight of aspirin and starch in a pellet. |
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