Studies with Polyfunctionally Substituted Heterocycles: Syntheses of Polyfunctionally Substituted Isoquinolines |
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| Authors: | Y M Elkholy |
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| Institution: | (1) Department of chemistry, Faculty of Science, Helwan University, AinHewan, Cairo-, Egypt |
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| Abstract: | The three-component reaction of acetaldehyde, cyanothioacetamide, and malononitrile results in 6-amino-3,5-dicyano-4-methylpyridine-2(1H)-thione. The latter reacts with different chemical reagents to afford new substituted isoquinolines and their fused derivatives, which show high fungicidal and bactericidal activities. |
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| Keywords: | electrophilic reagents isoquinoline pyridinethiones thieno[3 4-c]pyridine |
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