Synthesis and Cytotoxicity of 2‐(2′‐Pyridyl)benzimidazole Complexes of Palladium(II) and Platinum(II) |
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Authors: | Jos S Casas Alfonso Castieiras Emilia García‐Martínez Yolanda Paraj M Luz Prez‐Parall Angeles Snchez‐Gonzlez Jos Sordo |
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Institution: | José S. Casas,Alfonso Castiñeiras,Emilia García‐Martínez,Yolanda Parajó,M. Luz Pérez‐Parallé,Angeles Sánchez‐González,José Sordo |
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Abstract: | Compounds of type MX2(Hpben)] M = Pd (X = Cl), Pt (X = Cl, I); Hpben = 2‐(2′‐pyridyl)benzimidazole] were prepared and characterized, and the structures of the Pt derivatives were determined by X‐ray crystallography. The crystals of PtI2(Hpben)] consist of discrete units in which the Pt atom is coordinated to two iodine atoms and to pyridine and imidazole N atoms in a distorted square planar arrangement. The structure of the chloro derivative is similar, except that the PtCl2(Hpben)] monomers are hydrogen‐bonded in zig‐zag chains. In assays of the interactions of the Pd and Pt chloro compounds with DNA, and of their in vitro cytotoxic activity against human cervical carcinoma cells (HeLa‐229), human ovarian carcinoma cells (A2780) and a cisplatin‐resistant mutant A2780 line (A2780cis), the only activity observed was modest cytotoxicity of the Pd derivative for A2780. |
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Keywords: | Palladium Platinum 2‐(2′ ‐Pyridyl)benzimidazole Crystal structure Cytotoxic activity |
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