Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from <Emphasis Type="Italic">Symphytum officinale</Emphasis> roots and its biological activity |
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| Authors: | V Barbakadze A J J van den Berg C J Beukelman J Kemmink H C Quarles van Ufford |
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| Institution: | (1) Kutateladze Institute of Pharmaceutical Chemistry, ul. P. Saradzhishvili, 36, 0159 Tbilisi, Georgia;(2) Department of Medicinal Chemistry, Faculty of Pharmacy, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands |
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| Abstract: | Two high-molecular-weight (>1000 kDa) water-soluble biopolymers, the main component of which was poly3-(3,4-dihydroxyphenyl)glyceric
acid] or polyoxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene] according to IR and NMR spectroscopy, were isolated from roots
of Symphytum officinale. They exhibit antioxidant activity as expressed in a decrease of active oxygen species (AOS) by interfering
directly in their formation process by polymorphonuclear neutrophils (PMN) and binding directly AOS.
Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 9–12, January–February, 2009. |
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| Keywords: | Symphytum officinale 3-(3 4-dihydroxyphenyl)glyceric acid poly[oxy-1-carboxy-2-(3 4-dihydroxyphenyl)ethylene] antioxidant activity |
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