Enantioselective conjugate addition of alkenylboronic acids to indole-appended enones |
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Authors: | Lundy Brian J Jansone-Popova Santa May Jeremy A |
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Affiliation: | Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA. |
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Abstract: | An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3'-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)(2). A range of α-branched indole derivatives are available from the transformation. |
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