Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes |
| |
| Authors: | Roy Subhadeep Zanotti Kimberly J Murphy Connor T Tanious Farial A Wilson W David Ly Danith H Armitage Bruce A |
| |
| Affiliation: | Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. |
| |
| Abstract: | Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
